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Customer Rating 4.91

Patented Nootropics Formulation

WUKIYO® | esse functions as a whole-brain optimiser to support a state of peak overall mental performance.

· Increases focus and cognition.
· Enhances energy levels, concentration and creativity.
· Promotes mental clarity and supports long-term brain health.

  • Buy 2 Items - Get 10% Off
  • Delivery every 30 days. Pause or modify anytime.

Original price was: $54.Current price is: $42. or Original price was: $42.Current price is: $38. / month

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A Smarter Subscription

WUKIYO | esse™
Nootropics, reinvented.

es·​se \ ˈesē \

The Latin term meaning "to be".
Esse quam videri | a Latin phrase meaning "To be, rather than to seem".

Actual being | Existence
Essential nature | Essence

Martin Combs


"Love it! Everything in this has been provided and tested to increase mental acuteness. I might as well have superpowers because it allows me to have such a new outlook on how I get my tasks done. Truly a game changer product if you want to heighten awareness and increase mood ten-fold. The shot of joy typically comes within 30 minutes of taking this on on empty stomach and lasts well throughout the day with no crash or jittery feeling."

Dr. Morgan Hall


"WUKIYO | esse™ delivers the most comprehesive supplementation available in any nootropic stack I have seen. It is designed to deliver meaningful improvements to overall cognitive function. In addition to immediate neurochemical and physiological effects, goes a step further addressing long-term cognitive health benefits, especially important for persons wanting to optimize memory and brain health."

Rosie Wallen


"For me this product made me feel alert and aware. My mind felt clutter-free, I am able to focus on topics and feelings with a simple thinking process. My brain is always going! Like the fog is lifted and everything seems so simple. Thoughts came to me in a clear deices way. I got motivation and excitement for my life. I felt more energy and happiness. I got that urge back to learn, to observe, to be involved in my own life."

Certifiably Safe Products

We have gone through extensive processes to ensure our products are not only effective, but safe and compliant as well.

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NSF International verifies that products meet public health and safety standards. WUKIYO | esse™ passed with flying colors.

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The Food and Drug Administration (FDA) regulates the safety of food, drugs, and other consumer products. WUKIYO | esse™ fits the bill.


The World Anti-Doping Agency (WADA) monitors the fight against drugs in sports. WUKIYO | esse™ can keep you in the zone and in the game.


• Enhances memory, attention span, concentration, and the ability to learn.

• Helps the brain function under distress.

• Improved focus 12+ hours.

• Increased efficacy of neuronal firing.

• Enhanced verbal recall and executive functioning.

• Significantly improved mental processing.

• Heightened 'flow state', the feeling of being in the zone.

As Seen In

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Functional Ingredients. Functional Mind.

Patented, research-backed formulas made with the cleanest ingredients from science and nature.

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W-YO® | W-sensei™

L-Tyrosine300 mg

Curcumin250 mg + Piperine 3 mg

Phosphatidylserine250 mg

CRL-21X™100 mg

Phenibut HCL60 mg

Noopept10 mg

W-YO® | W-komorai™

Citicoline250 mg

Alpha-GPC200 mg

FL66™16 mg

Folate400 mcg

Magnesium200 mg

Vitamin K100 mcg

Vitamin D62.5 mcg

Organic Lion's Mane600 mg

CoEnzyme Q10100 mg

L-Theanine100 mg

Natural Caffeine90 mg

Vitamin B1, B6, B12100mg, 15mg, 1000mcg

The Patent.


W-YO® has been awarded a Notice of Allowance from the U.S. Patent and Trademark Office for our two proprietary nootropic molecules CRL-21X™ and FL66™.

Questions? We have answers

What is WUKIYO® | esse?

How does WUKIYO® | esse work?

What are primary, patented ingredients of the WUKIYO® | esse?

How should I use WUKIYO® | esse?

When should I use WUKIYO® | esse?

When will I begin to feel the effects?

How should I store WUKIYO® | esse and how long does it last?

Can I take any other stimulants with WUKIYO® | esse?

Will WUKIYO® | esse interact with my medications?

What is the main difference between WUKIYO® | esse and WUKIYO® | apex?


What are people saying about

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Customer Reviews

Customer Rating

4.89 based on 921 reviews

Customer Rating


based on 921 reviews


  1. Ron Overton

    Love this product! Ran out for few weeks, definitely noticed a difference.

  2. Neurohacker#1

    More than a supplement! I only take it when I know I’m going to need it. It simply works that well. If you really wanna understand what it does. You have to take it on an off day. When all you wanna do in melt into the couch.

  3. Rachel R.

    This supplement has been so helpful and has definitely improved overall cognitive function and flow state for teaching, studying, and even mind-muscle connection during my training sessions!

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